Home -
Products -
Endocrinology/Hormones -
5-HT Receptor -
NLX-204 hydrochloride(2170405-10-2 free base)
NLX-204 hydrochloride(2170405-10-2 free base)
CAS No.
NLX-204 hydrochloride(2170405-10-2 free base) ( —— )
Catalog No. M22899 CAS No.
NLX-204 hydrochloride is a potent and selective ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist(pKi = 10.19).NLX-204, displayed high selectivity in the SafetyScreen44 panel (including hERG channel), high solubility, metabolic stability, and Caco-2 penetration and did not block CYP3A4, CYP2D6 isoenzymes, or P-glycoprotein.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 219 | In Stock |
|
10MG | 366 | In Stock |
|
25MG | 515 | In Stock |
|
50MG | 751 | In Stock |
|
100MG | Get Quote | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
-
Product NameNLX-204 hydrochloride(2170405-10-2 free base)
-
NoteResearch use only, not for human use.
-
Brief DescriptionNLX-204 hydrochloride is a potent and selective ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist(pKi = 10.19).NLX-204, displayed high selectivity in the SafetyScreen44 panel (including hERG channel), high solubility, metabolic stability, and Caco-2 penetration and did not block CYP3A4, CYP2D6 isoenzymes, or P-glycoprotein.
-
DescriptionNLX-204 hydrochloride is a potent and selective ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist(pKi = 10.19).NLX-204, displayed high selectivity in the SafetyScreen44 panel (including hERG channel), high solubility, metabolic stability, and Caco-2 penetration and did not block CYP3A4, CYP2D6 isoenzymes, or P-glycoprotein.Preliminary in vivo studies confirmed its promising pharmacokinetic profile.NLX-204 also robustly stimulated ERK1/2 phosphorylation in rat cortex and showed highly potent (MED = 0.16 mg/kg) and efficacious antidepressant-like activity, totally eliminating immobility in the rat Porsolt test.
-
Synonyms——
-
PathwayEndocrinology/Hormones
-
Target5-HT Receptor
-
Recptor5-HT1A
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number--
-
Formula Weight409.13
-
Molecular FormulaC20H23Cl2F2N3O2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES[H]Cl.O=C(C1=CC=C(F)C(Cl)=C1)N2CCC(CNCCOC3=NC=CC=C3)(F)CC2
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Sniecikowska, Joanna, Guch-Lutwin, Monika, Bucki, Adam,et al. Novel aryloxyethyl derivatives of 1-(1-benzoylpiperidin-4-yl)methanamine as the Extracellular Regulated Kinases 1/2 (ERK1/2) phosphorylation-preferring serotonin 5 HT1A receptor biased agonists with robust antidepressant-like activity[J]. Journal of Medicinal Chemistry, 2019.
molnova catalog
related products
-
Pardoprunox
Pardoprunox(SLV-308) is a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist.
-
NSC23005
NSC23005 sodium is a p18INK inhibitor with potently promoted hematopoietic stem cell (HSC) expansion (ED50: 5.21 nM).
-
Promethazine
Tafluprost(AFP-168) is an anti-glaucoma prostaglandin (PG) analog.